Arizona Cardinals

Sept. 8 San Diego, 4:20 p.m.

Sept. 14 at N.Y. Giants, 10 a.m.

Sept. 21 San Francisco, 1:05 p.m.

Sept. 28 BYE

Oct. 5 at Denver, 1:05 p.m.

Oct. 12 Washington, 1:25 p.m.

Oct. 19 at Oakland, 1:25 p.m.

Oct. 26 Philadelphia, 1:05 p.m.

Nov. 2 at Dallas, 10 a.m.

Nov. 9 St. Louis, 1:25 p.m.

Nov. 16 Detroit, 1:25 p.m.

Nov. 23 at Seattle, 1:05 p.m.

Nov. 30 at Atlanta, 1:05 p.m.

Dec. 7 Kansas City, 1:05 p.m.

Dec. 11 at St. Louis, 5:25 p.m.

Dec. 21 Seattle, 5:30 p.m.

Dec. 28 at San Francisco, 1:25 p.m.

St. Louis Rams

Sept. 7 Minnesota, 10 a.m.

Sept. 14 at Tampa Bay, 1:05 p.m.

Sept. 21 Dallas, 10 a.m.

Sept. 28 BYE

Oct. 5 at Philadelphia, 10 a.m.

Oct. 13 San Francisco, 4:30 p.m.

Oct. 19 Seattle, 10 a.m.

Oct. 26 at Kansas City, 10 a.m.

Nov. 2 at San Francisco, 1:05 p.m.

Nov. 9 at Arizona, 1:25 p.m.

Nov. 16 Denver, 10 a.m.

Nov. 23 at San Diego, 1:05 p.m.

Nov. 30 Oakland, 10 a.m.

Dec. 7 at Washington, 10 a.m.

Dec. 11 Arizona, 5:25 p.m.

Dec. 21 N.Y. Giants, 1:05 p.m.

Dec. 28 at Seattle, 1:25 p.m.

San Francisco 49ers

Sept. 7 at Dallas, 1:25 p.m.

Sept. 14 Chicago, 5:30 p.m.

Sept. 21 at Arizona, 1:05 p.m.

Sept. 28 Philadelphia, 1:25 p.m.

Oct. 5 Kansas City, 1:25 p.m.

Oct. 13 at St. Louis, 4:30 p.m.

Oct. 19 at Denver, 5:30 p.m.

Oct. 26 BYE

Nov. 2 St. Louis, 1:05 p.m.

Nov. 9 at New Orleans, 10 a.m.

Nov. 16 at N.Y. Giants, 10 a.m.

Nov. 23 Washington, 1:25 p.m.

Nov. 27 Seattle, 5:30 p.m.

Dec. 7 at Oakland, 1:25 p.m.

Dec. 14 at Seattle, 1:25 p.m.

Dec. 20 San Diego, TBD.

Dec. 28 Arizona, 1:25 p.m.

Seattle Seahawks

Sept. 4 Green Bay, 5:30 p.m.

Sept. 14 at San Diego, 1:05 p.m.

Sept. 21 Denver, 1:25 p.m.

Sept. 28 BYE

Oct. 6 at Washington, 5:30 p.m.

Oct. 12 Dallas, 1:25 p.m.

Oct. 19 at St. Louis, 10 a.m.

Oct. 26 at Carolina, 10 a.m.

Nov. 2 Oakland, 1:25 p.m.

Nov. 9 N.Y. Giants, 1:25 p.m.

Nov. 16 at Kansas City, 10 a.m.

Nov. 23 Arizona, 1:05 p.m.

Nov. 27 at San Francisco, 5:30 p.m.

Dec. 7 at Philadelphia, 1:25 p.m.

Dec. 14 San Francisco, 1:25 p.m.

Dec. 21 at Arizona, 5:30 p.m.

Dec. 28 St. Louis, 1:25 p.m.

Crown of thorns

Seattle has never been a defending champion. But Pete Carroll has.

His blueprint for keeping the Seahawks elite involved locking up All-Pros cornerback Richard Sherman and safety Earl Thomas, plus receiver Doug Baldwin, to contract extensions, re-signing DE Michael Bennett, and never resting on what happened last season. The Seahawks also avoided a contract dispute with RB Marshawn Lynch and have seen glimpses of the punch a healthy WR Percy Harvin could add to their offense.

Their defense might not match the suffocating numbers posted a year ago, but if quarterback Russell Wilson and the offense continues to evolve, the Seahawks might not need the best defense to remain atop the division.

“If you’re going to have a good team you’re going to have to deal with these guys and these good teams, so that’s what we’re faced with,” Carroll said. “Whoever comes out on top of the division is really going to be ready to play anybody.”

Last exit

Just off Highway 101, the 49ers move into their new palatial home this season — Levi’s Stadium — replacing the outdated Candlestick Park, and trying to regain their perch atop the division.

QB Colin Kaepernick is locked up long term and he will have tight end Vernon Davis, WRs Michael Crabtree, Anquan Boldin and Stevie Johnson as targets all season. Frank Gore and rookie Carlos Hyde will be the featured backs of an offense that again will rely heavily on the run.

Defensively there are more concerns. The secondary has been completely remodeled since the Niners’ Super Bowl appearance two seasons ago. Bowman likely won’t be back until at least midseason after a gruesome knee injury in the NFC championship game and there is no clarity on any discipline LB Aldon Smith may face for off-field troubles.

“For us, we have been close. We did go one year. That’s not good enough, we want to bring it home,” linebacker Patrick Willis said.

Hill to climb

The defense Jeff Fisher has built in St. Louis is impressive. Whether the Rams can jump into contention will fall onto the arm of backup quarterback Shaun Hill.

Franchise QB Sam Bradford tore his ACL for the second straight season — the final year of his rookie contract — and Fisher has handed the reins to Hill, a 34-year-old journeyman who last started a game in 2010 with Detroit.

The Rams added Kenny Britt to give them a target opposite second-year wide receiver Tavon Austin, and the addition of rookie Greg Robinson should solidify the left side of the offensive line.

St. Louis has a dominant front four on defense with Chris Long, Robert Quinn, Michael Brockers and the addition of rookie Aaron Donald. But the secondary must improve.

Big wave

Arizona was one of the hottest teams at the end of last season after finally clicking under coach Bruce Arians, winning seven of its final nine. The Cardinals also hold the distinction of being the only team to win in Seattle since 2011 after knocking off the Seahawks in Week 16.

Quarterback Carson Palmer has another year in Arians’ system and Larry Fitzgerald remains an elite pass catcher.

Andre Ellington established himself as Arizona’s leading rusher with 652 yards and three touchdowns in his rookie season.

But the Cardinals are struggling to replace LBs Karlos Dansby and Daryl Washington, and DE Darnell Dockett tearing his ACL is another significant loss.

The secondary could be second best in the NFC behind Seattle thanks to incumbent CB Patrick Peterson and the additions of Antonio Cromartie and rookie Deone Bucannon.

“I really like the way our team battled through the second half of the season,” Arians said. “It makes this one more important and easier to get started.”

— The Associated Press