'Reverse vaccine' for diabetes passes test

Los Angeles Times /


Published Jun 30, 2013 at 05:00AM / Updated Nov 19, 2013 at 12:31AM

A “reverse vaccine” that allows people with Type 1 diabetes to produce their own insulin has passed its first test with human subjects, according to a new study. The success points to a potential new strategy for treating those in the early stages of the disease.

The therapy is designed to protect cells in the pancreas that make insulin, a hormone the body needs to convert sugars and starches into energy. In people with Type 1 diabetes, the immune system goes haywire and attacks those crucial insulin-producing cells for reasons that medical researchers don’t understand.

Researchers dubbed the treatment a reverse vaccine because it suppresses the immune system instead of stimulating it. As hoped, the experimental vaccine reduced the number of immune system “killer” cells that went on the attack.

No significant side effects or safety concerns arose during the study.

About 1.25 million Americans have Type 1 diabetes. For 100 years, the standard treatment has been insulin replacement therapy in which insulin is injected in amounts that correspond with blood sugar levels.