10 a.m., Denver Broncos (7-3) at Kansas City Chiefs (1-9), CBS: Denver QB Peyton Manning leads the AFC in passer rating (106.2) and TD passes (24). The Chiefs have averaged 12 points per game during a seven-game losing streak.
10 a.m., Seattle Seahawks (6-4) at Miami Dolphins (4-6), Fox: Seattle is off to its best start in five years but is only 1-4 on road. Miami QB Ryan Tannehill has five interceptions in the past two games and 11 overall.
1 p.m., San Francisco 49ers (7-2-1) at New Orleans Saints (5-5), Fox: A rematch of the divisional-round slugfest the two teams engaged in last year in San Francisco. The quarterback situation is up in the air for the 49ers, between Alex Smith and Colin Kaepernick (story, D6).
5:20 p.m., Green Bay Packers (7-3) at New York Giants (6-4), NBC: The Packers have won five straight after a 2-3 start. The Giants are coming off a bye.